Find out what Deflux treatment involves

Refer to a pediatric urologist for treatment with Deflux

Deflux has been FDA-approved in the United States for use in children with reflux grades II-IV since 2001. Endoscopic treatment with Deflux takes about 15 minutes on an outpatient basis and usually allows the child to go back to normal activities the day after it’s done.

Deflux should only be administered by qualified surgeons experienced in the use of a cystoscope and trained in subureteral injection procedures and must not be injected intravascularly as injection into blood vessels may cause vascular occlusion.

Please refer your appropriate patients with vesicoureteral reflux (VUR) to a pediatric urologist upon VUR diagnosis.

Before the availability of endoscopic treatment options such as Deflux, patients with VUR were either placed on continuous antibiotic prophylaxis (CAP), left untreated while being observed for recurrent infection, or offered open surgical reimplantation.1

Treatment of appropriate patients with vesicoureteral reflux (VUR) using Deflux is usually carried out after a period of antibiotic prophylaxis. First, VUR should be confirmed by VCUG investigation.1

Deflux is the most preferred method for VUR treatment2

80% of parents surveyed preferred endoscopic treatment rather than antibiotic prophylaxis or open surgery.

Taking into account the VUR treatment options preferred by parents of children with grade III VUR, investigators proposed a treatment algorithm with endoscopic treatment as first-line treatment for persistent VUR.

Open surgery is recommended for severe cases or those who have failed endoscopic treatment.


  1. American Urological Association Pediatric Vesicoureteral Reflux Clinical Guidelines Panel. Report on the Management of Primary Vesicoureteral Reflux in Children. Linthicum, MD: American Urological Association; 1997.
  2. Capozza N, Lais A, Matarazzo E, Nappo S, Patricolo M, Caione P. Treatment of vesicoureteric reflux: a new algorithm based on parental preference. BJU Int. 2003;92(3):285-288. DOI: 10.1046/j.1464-410x.2003.04325.x