About Deflux


The minimally invasive, recommended first-line treatment for immediate protection against VUR1,2

Evidence indicated that endoscopic injection is effective for the treatment of most VUR, while emphasizing the importance of pre-operative reflux grade and structural/functional bladder abnormalities in ultimate treatment success.1

Patients undergoing successful Deflux treatment receive immediate protection against further reflux associated renal damage, without the need for adherence to a long-term treatment regimen and continued reflux testing.1,3

Endoscopic treatment with Deflux not only approached success rates of open repair but offers significant advantages to patients and parents: outpatient surgery, lower morbidity (e.g., pain, scar), fewer complications and reduced cost.3,4

It was suggested that with the advent of Deflux, endoscopic therapy has become the first-line therapy for many patients with reflux.1


  1. Sung J, Skoog S. Surgical management of vesicoureteral reflux in children. Pediatr Nephrol. 2012;27:551-561.
    DOI: 10.1007/s00467-011-1933-7
  2. Elder JS, Shah MB, Batiste LR, Eaddy M. Part 3: Endoscopic injection versus antibiotic prophylaxis in the reduction of urinary tract infection in patients with vesicoureteral reflux. Curr Med Res Opin. 2007;23(4):S15-20. DOI: 10.1185/030079907X226230
  3. Hensle TW, Grogg AL. Part 1: Vesicoureteral reflux treatment: The past, present and future. Curr Med Res Opin. 2007;23(4):S1-S5. DOI: 10.1185/030079907X226212
  4. Cerwinka WH, Scherz HC, Kirsch AJ. Endoscopic treatment of vesicoureteral reflux with dextranomer/hyaluronic acid in children. Adv Urol. 2008; 1-7. DOI: 10.1155/2008/513854