22 May Uropathogen Resistance and Antibiotic Prophylaxis: A Meta-analysis

Continuous antibiotic prophylaxis increases the risk of acquired multidrug resistance among recurrent UTIs. One multidrug-resistant recurrent UTI would develop for every 21 VUR patients treated with prophylaxis. These results have important implications in the selection of empirical treatment of breakthrough UTIs in continuous antibiotic prophylaxis patients and in the risk-benefit assessment of continuous antibiotic prophylaxis as a management option for prevention of recurrent UTIs. Additional study of other commonly used antimicrobial prophylactic agents and further investigation of risk factors related to the development of uropathogen resistance are necessary.