Get the facts on the safety of Deflux

Deflux Is Safe

Deflux has been used safely and effectively for well over 20 years1

The first question most parents ask about Deflux is, “How safe is it?” Your child’s well-being is your #1 priority, so you will want to take a long, hard look at any potential treatment.

Since 2001, in the U.S., Deflux has been used to treat vesicoureteral reflux (VUR) grades II-IV in children. The hyaluronic acid (HA) gel itself is sugar-based and is similar to the natural starches, sugars and tissues in the body.

The risk of infection and bleeding with the procedure is low2

The following adverse events have been reported with Deflux (occurring 1%): blockage of the ureters (some cases require temporary placement of a ureteric stent), painful urination, blood in the urine, urgency of urination, frequency of urination, swelling of the kidneys, inflammation of the kidneys, urinary tract infection, foreign body reaction, calcification and fever.

  • Safety and efficacy of Deflux in children under one year of age have not been established
  • Safety and efficacy of Deflux in duplex kidney systems have not been established
References:
  1. Cerwinka WH, Scherz HC, Kirsch AJ. Endoscopic treatment of vesicoureteral reflux with dextranomer/hyaluronic acid in children. Advances in Urology. 2008; 1-7.
  2. Deflux [prescribing information]. Santa Barbara, CA: Palette Life Sciences, Inc.; 2019.