Read the answers to common questions about Deflux

Common Questions About Deflux

How do I know Deflux will work for my child?

Most children have success after one injection, while some may need more injection procedures. A 2011 study shows Deflux was proven effective in 93% of children, with no febrile urinary tract infections (febrile UTIs) after one injection.1

How safe is Deflux?

Since 2001, Deflux has been used to treat vesicoureteral reflux (VUR) grades II-IV. The gel is similar to the natural starches, sugars and tissues in the body.

The following adverse events have been reported with Deflux (occurring 1%): blockage of the ureters (some cases require temporary placement of a ureteric stent), painful urination, blood in the urine, urgency of urination, frequency of urination, swelling of the kidneys, inflammation of the kidneys, urinary tract infection, foreign body reaction, calcification and fever.

Who should not be treated with Deflux?

Children with certain types of medical conditions should not be treated with Deflux:

  • Non-functional kidney(s)
  • Hutch diverticulum (bulging or herniation in the skin of the bladder)
  • Ureterocele (swelling at the bottom of the ureter)
  • Acute voiding dysfunction (disorder in eliminating urine)
  • Ongoing UTIs

Why should I get my child treated for VUR if my pediatrician doctor says he or she may grow out of it?

Some children do outgrow VUR, usually when it’s a mild case. This is what your pediatrician doctor or pediatric urologist calls spontaneous resolution.

The likelihood of spontaneous resolution varies according to a child’s age, grade of VUR, and whether the VUR is on one side or both.

According to the American Urological Association, for a child between the ages of 2-5 years old with grade III VUR (in one ureter), the chance of VUR resolving without treatment is between 13.4% (at 1 year) and 51.3% (at 5 years). For a child between the ages of 5-10 years old with grade III VUR (in both ureters), the chance of VUR resolving without treatment is between 2.6% (at 1 year) and 12.5% (at 5 years).

Treatment is important to protect the kidneys. Kidney infections may cause damage or scarring in the kidneys, which can result in poor kidney function and high blood pressure.

Significantly more VUR patients with renal scarring developed proteinuria (5.1% vs 1.6%) and kidney disease (2% vs 0%). Hypertension occurred in 2.8% of patients with renal scarring and 1% of those without.

What’s the best treatment for my child?

This is a discussion you should have with your pediatrician doctor and a pediatric urologist. In most cases, you have the option of antibiotics, endoscopic treatment with Deflux, or open surgery—all of which have their specific benefits and risks. You want to make sure you understand all that’s involved, from treatment to required follow-up. Only then can you decide what’s right for your family.

References:
  1. Kalisvaart JF. Intermediate to long-term follow-up indicates low risk of recurrence after double hit endoscopic treatment for primary vesicoureteral reflux. J Ped Urol. 2012;8(4):359-365.