How effective is DEFLUX?

The success rate for DEFLUX is high, but on average not as high as open surgery. Initial investigations with DEFLUX indicated that 68% of patients with VUR can expect to be cured.1

However, subsequent studies have reported an improvement in the response rate, with cure achieved in 71% of patients2 or 86% of treated ureters after a single DEFLUX injection.3

What if it doesn’t work?

The majority of children are cured after one treatment.4 However, if a single treatment of DEFLUX does not prove successful, your child may need additional injections.

Many doctors and parents appreciate the fact that if DEFLUX fails to cure VUR then surgery is still an option. The gel injection does not preclude, complicate or in any way prevent surgery later. 

How does the DEFLUX procedure compare to surgery?

Of the two treatments for VUR, surgery has the highest cure rate, with DEFLUX being second. Most parents and doctors who consider endoscopic treatment with DEFLUX weigh the trade off in efficacy with the fact that DEFLUX is less invasive. And if treatment with DEFLUX does not work for your child, surgery is still an option.

 

 


  1. Läckgren G, Wåhlin N, Sköldenberg E, et al. Long-term follow-up of children treated with dextranomer/hyaluronic acid copolymer for vesicoureteral reflux. J Urol 2001; 166: 1887-92.
  2. Kirsch AJ, Perez-Brayfield M, Smith EA, et al. The modified STING procedure to correct vesicoureteral reflux: improved results with submucosal implantation within the intramural ureter. J Urol 2004; 171: 2413-6.
  3. Puri P, Chertin B, Velayudham M, et al. Treatment of vesicoureteral reflux by endoscopic injection of dextranomer/hyaluronic acid copolymer: preliminary results. J Urol 2003; 170: 154- 4.
  4. Kirsch AJ, Perez-Brayfield MR, Scherz HC. Minimally invasive treatment of vesicoureteral reflux with endoscopic injection of dextranomer/hyaluronic acid copolymer: the Children’s Hospitals of Atlanta experience. J Urol. 2003;170:211-215.